venofer dosing calculator

Before using, check this product visually for particles or discoloration. Applies only to oral form of both agents. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. Although the original formula requires the weight in kilograms, values input in lbs are transformed. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Administer a test INFeD dose prior to the first therapeutic dose. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Minor/Significance Unknown. The recipient will receive more details and instructions to access this offer. Applies only to oral form of both agents. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. Separate dosing of tetracyclines from these products. Consult your doctor before breast-feeding. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. Objective. Applies only to oral form of both agents. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Use Caution/Monitor. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Use Caution/Monitor. iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Injection site discoloration has been reported following extravasation. Individual plans may vary Applies only to oral form of both agents. Applies only to oral form of both agents. If we don't have the calculator you need we'll try to make it for you and add it to the website. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Last updated on Jun 1, 2022. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Avoid or Use Alternate Drug. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Avoid or Use Alternate Drug. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Controlled studies in pregnant women show no evidence of fetal risk. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. Max Dose. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Uses for Iron Sucrose The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. informational and educational purposes only. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. 1988 May;111(5):566-70. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Copyright(c) 2023 First Databank, Inc. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. This website also contains material copyrighted by 3rd parties. These can be input in g/dL, g/L or mmol/L. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Use Caution/Monitor. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Applies only to oral form of both agents. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Sodium ferric gluconate (Ferrlecit) 62.5 mg . For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Venofer treatment may be repeated if necessary. Deferoxamine chelates iron. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Use Caution/Monitor. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Administer Venofer early during the dialysis session (generally within the first hour). Applies only to oral form of both agents. Deferoxamine chelates iron. Use Caution/Monitor. Suggested regime: Prescribing instructions Prescribing a single/first dose: Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Modify Therapy/Monitor Closely. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? J Med. Deferasirox chelates iron. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). Use Caution/Monitor. The iron formulation choice remains for the clinician to make. Applies only to oral form of both agents. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Applies only to oral form of both agents. Applies only to oral form of both agents. Observed Hb = the patients current hemoglobin in g/dl. Initial infusion rate. Avoid or Use Alternate Drug. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. 2015: 763576. Official Journal of the International Society of Nephrology. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Venofer [package insert]. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Formula for calculating the required dose of iron sucrose 1. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. official version of the modified score here. Monitor Closely (1)trientine, iron sucrose. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. This calculator will help pinpoint potential causes of anemia based on Each mL contains 20 mg of elemental iron. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Avoid or Use Alternate Drug. Your doctor will do laboratory tests to monitor your response. Use alternatives if available. 2. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Use Caution/Monitor. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Found in multiple references. Minor/Significance Unknown. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. *Administer early during the dialysis session. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Use Caution/Monitor. Access your plan list on any device mobile or desktop. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. 1) Ganzoni AM. This drug is available at a higher level co-pay. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. I. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. Use Caution/Monitor. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Either increases effects of the other by pharmacodynamic synergism. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Separate by 2 hr. Accessed: 4/12/2011. Dosing Administration & Considerations . Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Most Use alternatives if available. Learn how to store and discard medical supplies safely. trientine, iron sucrose. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or https://www.uptodate.com/ (Requires subscription). Adding plans allows you to compare formulary status to other drugs in the same class. ONE DOSE. Accessed: 4/12/2011. Avoid or Use Alternate Drug. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Read our. Either decreases levels of the other by inhibition of GI absorption. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. Applies only to oral form of both agents. Use Caution/Monitor. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Use Caution/Monitor. Do not double the dose to catch up. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . iron sucrose decreases levels of manganese by inhibition of GI absorption. Ganzoni AM. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Interaction only with oral iron administration. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. You will have to pay for your IV iron. Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. DICP. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Avoid or Use Alternate Drug. Monitor for signs and symptoms of hypotension following each Feraheme infusion. LBW = Lean body weight in kg. Applies only to oral form of both agents. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Monitor for signs and symptoms of hypotension following each administration of Venofer. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Administer on 5 different occasions over a 14 day period. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. This topic . Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Diagnosis and management of iron deficiency anaemia: a clinical update. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Use Caution/Monitor. Do Not Copy, Distribute or otherwise Disseminate without express permission. You may need extra iron because of blood loss during kidney dialysis. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. Applies only to oral form of both agents. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Separate dosing of tetracyclines from these products. 1995 Mar-Apr;11(2):163-8. Applies only to oral form of both agents. Applies only to oral form of both agents. For liquid medications, also enter the value of the Medicine Concentration and choose . Oral and parenteral products - see background option for oral products. Modify Therapy/Monitor Closely. Minor/Significance Unknown. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Anemia. Contraindicated. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. Applies only to oral form of both agents. Separate by 2 hr. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Interaction only with oral iron administration. Volume of iron product required = 25 mL. Where C= concentration of Can't find what you need? Calculates iron deficit for dosing iron. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Minor/Significance Unknown. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Use Caution/Monitor. Applies only to oral form of both agents. The above information is provided for general iron sucrose increases levels of calcium citrate by enhancing GI absorption. Use Caution/Monitor. Applies only to oral form of both agents. Parenteral iron supplementation. This site complies with the HONcode standard for trust- worthy health information: verify here. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. May increase risk of hypotension. Schweiz Med Wochenschr; 100(7):301-3. Use Caution/Monitor. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Venofer treatment may be repeated if iron deficiency reoccurs. Baloxavir may bind to polyvalent cations resulting in decreased absorption. 1970; 100(7):301-3. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Applies only to oral form of both agents. We have found the lower dose to be better tolerated in the second half of gestation. https://www.uptodate.com/ (Requires subscription). Manage and view all your plans together even plans in different states.

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